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Anti-angiogenesis approach to fight
cancer
In what has been termed as the "fourth arm" of cancer
treatment, (chemotherapy, radiation therapy and surgery are numbers one, two and
three) angiogenesis inhibitors have been hailed as a significant advance in the
long fight against cancer. Instead of aiming their firepower at tumours
themselves, anti-angiogenic inhibitors do not have the harsh side effects of
conventional cancer treatment.
CNN reported recently that cancer needs a growing network
of blood vessels to survive. Shutting down this process called angiogenesis
should arrest tumours or even destroy them. Recent clinical trials of an
experimental drug, conducted at Duke University, confirmed that cutting off a
tumor's blood supply could improve cancer survival.
 
Researchers at Ohio State University Medical Center
(Columbus, Ohio), University of Kuopio (Kuopio, Finland), and Creighton
University Medical Center (Omaha, Nebraska) have shown that Optivin
significantly inhibits angiogenesis both in vitro and in vivo, thus offering
potential benefit in the treatment of related disorders such as cancer and
inflammation.
"For the past 50 years, almost all cancer therapy has
been aimed at the cancer cell. But this cell can quickly become drug-resistant
and conventional therapy has harsh side effects. Unlike chemotherapy, angiogenic
inhibitors will be used on a long-term basis because they are non-toxic and do
not generate drug resistance."
Dr.
Judah Folkman
World-renowned Harvard surgeon,
Founding father of
Angiogenesis
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HELICOBACTER PYLORI
BACTERIA
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Helicobacter pylori (H. pylori) is a spiral-shaped
bacterium (germ) that causes chronic inflammation (gastritis) and peptic ulcer
disease (sores on the lining of the stomach or small intestine) in humans. It
lives on the gastric epithelium under the mucus layer of stomach and duodenum
(section of intestine just below stomach. The bacterium is thought to damage
this mucus layer which is the stomach and duodenum's natural protection from
gastric acids. Local inflammation caused by the bacterial infection and exposure
to these acids can damage the lining of the stomach and duodenum, eventually
leading to ulceration and possibly gastric cancer.
The bacterium was first discovered in 1982 by two
Australian scientists Robin Warren and Barry Marshall. This bacteria is the most
common cause of ulcers worldwide. Approximately half of the world's population
is infected with H. pylori, which produces free radicals. The World Health
Organisation has declared h'pylori as a carcinogen causing infected people to
contract gastritis, stomach ulcers, colon and gastric cancer.
Right now, there is no vaccine against H. pylori.
Although research suggests that infection is passed from person to person,
exactly how this happens is not really known. Because transmission is not
clearly understood, prevention guidelines are not yet available. With prolonged
antibiotic therapy, H. pylori gastritis and peptic ulcer disease (especially
ulcers in the duodenum, a portion of the small intestine) can often be cured.
Biaxin is one of the strongest antibiotic used to treat
h.pylori infection, but it has been found to become antibiotic resistant.
Besides killing bacteria, antibiotics also kill normal healthy cells.
H. pylori infection can be diagnosed with a blood test.
Your doctor might also want you to get an x-ray or have endoscopy (an endoscope
is a thin tube that carries a tiny camera) to see if you have an ulcer. A urea
breath test is another way to find out if you have H. pylori infection.
Once a person is infected, the organism can live in the
stomach indefinitely and may not cause clinical illness until many years later.
There is a general consensus among doctors that patients should be treated if
they are infected with H.pylori and have ulcers. The goal of treatment is to
eradicate the bacteria, heal the ulcers, and prevent the ulcers' return.
OPTIVIN™ 's ability to inhibit the growth of H. pylori
has been evaluated and backed by the first published study of various berry
extracts against this bacteria.
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What Experts Say
“It's hard to go wrong if you fortify your diet with
colorful foods. Almost every one of them is loaded with disease-proofing
compounds.
The
Color Code
James A Joseph, Ph.D., Daniel A. Nadeau, M.D., and Anne Underwood
"Fruits and vegetables with the deepest colors generally
are most beneficial because they contain high levels of
antioxidants."
Jean
Carpenter
Author of bestseller
"Stop Aging Now"
"Rats injected with cancer causing agents and then fed a
berry-rich diet had 80 per cent fewer malignant tumours compared to those
without berries in their diet."
Gary
Stoner, Ph.D, Biologist
Ohio State University
In light of the increasing antibiotic resistance of many bacteria, the public
health significance of the role of foods, such as cranberry, in preventing
infections warrants further consideration. A lower number of infections means
reduced use of antibiotics and lower potential risk of developing further
bacterial antibiotic resistance."
Betsy Foxman,
Professor of Epidemiology and director at the Center for Molecular and Clinical
Epidemiology, University of Michigan School of Public Health
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"Older animals with impairments in learning, memory and
coordination begin to show significant signs of improvement after a 2-month diet
of blueberries. Anthocyanins found in the fruit appears to have triggered the
birth of new neurons - an act called neurogenesis - making the brain look and
act like a younger one."
Barbara Shukitt-Hale, Ph.D.
USDA Scientist,
Neuroscience Laboratory
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